Four different serotype variants of dengue
This has been revealed in the serotype test of blood samples of dengue positive patients by the microbiology department of SGPGIMS under the National Infectious Disease Control Program. Professor Ujjwala Ghoshal, Head, Department of Microbiology, SGPGI, said that dengue infection is caused by a virus of the Flaviridae family. It has four different serotype variants D1, D2, D3 and D4. They cause dengue infection.
D2 variant is the most dangerous
The most dangerous D2 variant of dengue has been found in maximum number of patients in the capital. Ghoshal says, “Dengue serotype detection by RT-PCR is routinely done at SGPGIMS. Some of these samples are tested for serotyping. In 2022, D-2 serotype is most prevalent in Lucknow , followed by the D3 serotype; some cases of mixed infection with the D-2 and D-3 serotypes have also been detected.”
The D3 variant was revealed last year
Professor Atul Garg, co-in-charge of SGPGI’s virology lab, said dengue serotypes in circulation change annually. Last year D3 serotype was most common followed by D2. In the last few years minimum number of D-4 cases have been reported from the city. “As per the national data, D2 is the most prevalent dengue variant in India in the last 50 years,” he added. According to experts, the D2 strain (serotype 2 or DENV-2) of dengue virus is known to be the most dangerous strain and can make the disease severe.
D2 variant was spread in western UP last year
In October last year, the D2 variant emerged behind a rise in fever cases and deaths in the districts of Firozabad, Agra, Mathura and Aligarh in western UP. He also said that earlier 20 out of 100 positive patients were admitted in the hospital which has reached 30%. Similarly, earlier only 1% patients required ICU care but this year around 5% patients require ICU care.
These are the features of the D2 variant
D2 High fever, vomiting, joint pain are its main symptoms. Even this new variant can cause fatal complications resulting in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Explaining why people get serious complications due to dengue, Professor S Verma, KGMU Department of Microbiology, said, “Recovery from infection is believed to confer long-term immunity against that serotype. However, other serotypes after recovery Immunity against is only partial and temporary.”